InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ly96

Summary

InnateDB Protein

IDBP-135443.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ly96

Protein Name

lymphocyte antigen 96

Synonyms

ESOP-1; MD-2; MD2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026881

InnateDB Gene

IDBG-135441 (Ly96)

Protein Structure

UniProt Annotation

Function

Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Highly expressed in spleen, bone marrow, thymus, liver, kidney, ovary and decidua. Detected at lower levels in testis, small intestine and skin.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001875	lipopolysaccharide receptor activity
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032497	detection of lipopolysaccharide
GO:0045087	innate immune response (InnateDB)