InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ly96

Summary

InnateDB Gene

IDBG-135441.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ly96

Gene Name

lymphocyte antigen 96

Synonyms

ESOP-1; MD-2; MD2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025779

Encoded Proteins

IDBP-135443

lymphocyte antigen 96

IDBP-788730

lymphocyte antigen 96

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21712422

Tlr4::Ly96 functions as intracellular LPS sensor and triggers a unique set of LPS responses upon recognition of phagocytosed bacteria in macrophages.

PMID 22433852

Amino acid Phe126 of Ly96 acts as a hydrophobic switch driving agonist-dependent contacts necessary for Tlr4 dimerization and activation. (Demonstrated in human)

PMID 22474354

Morphine binds to Ly96, triggering Tlr4 oligomerization and induces neuroinflammation within the central nervous system. (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 19840871

[Homo sapiens] LY96 (MD-2) recognizes only exogenous pathogen-associated molecular patterns (PAMPs) when complexed with TLR2-CD14 or TLR4-CD14.

PMID 15852007

[Homo sapiens] LY86 and CD180 interact directly with the TLR4 signalling complex, inhibiting its ability to bind microbial ligand.

PMID 10359581

[Homo sapiens] LY96 is physically associated with TLR4 on the cell surface and confers responsiveness to lipopolysaccharide (LPS).

PMID 21712422

[Homo sapiens] TLR4::LY96 functions as intracellular LPS sensor and triggers a unique set of LPS responses upon recognition of phagocytosed bacteria in macrophages. (Demonstrated in murine model)

PMID 22433852

[Homo sapiens] Amino acid Phe126 of LY96 acts as a hydrophobic switch driving agonist-dependent contacts necessary for TLR4 dimerization and activation.

PMID 22474354

[Homo sapiens] Morphine binds to LY96, triggering TLR4 oligomerization and induces neuroinflammation within the central nervous system.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154589:
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:16688051-16709611

Strand

Forward strand

Band

Transcripts

ENSMUST00000026881	ENSMUSP00000026881
ENSMUST00000191260
ENSMUST00000190366	ENSMUSP00000140411

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001875	lipopolysaccharide receptor activity
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032497	detection of lipopolysaccharide
GO:0045087	innate immune response (InnateDB)