InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sema3e

Summary

InnateDB Protein

IDBP-135742.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sema3e

Protein Name

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

Synonyms

6430702L12; AA408817; mKIAA0331; Semah;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073612

InnateDB Gene

IDBG-135740 (Sema3e)

Protein Structure

UniProt Annotation

Function

Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down- regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation. {ECO:0000269PubMed:15550623, ECO:0000269PubMed:19421194, ECO:0000269PubMed:20385769, ECO:0000269PubMed:22179111}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Detected in neurons in the thalamus. Detected in embryonic vasculature. Developing lungs, developing skeletal elements and ventral horns of the developing neural tube. Correlates positively with tumor progression. {ECO:0000269PubMed:15550623, ECO:0000269PubMed:22179111}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030215	semaphorin receptor binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001953	negative regulation of cell-matrix adhesion
GO:0002040	sprouting angiogenesis
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0008360	regulation of cell shape
GO:0016525	negative regulation of angiogenesis
GO:0030154	cell differentiation
GO:0050808	synapse organization
GO:0071526	semaphorin-plexin signaling pathway
GO:2000249	regulation of actin cytoskeleton reorganization

Cellular Component

GO:0005576	extracellular region
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1340034

InterPro

IPR001627 Sema domain
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR016201 Plexin-like fold

PFAM

PF01403
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00630
SM00409
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70275