InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sema3e

Summary

InnateDB Gene

IDBG-135740.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sema3e

Gene Name

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

Synonyms

6430702L12; AA408817; mKIAA0331; Semah

Species

Mus musculus

Ensembl Gene

ENSMUSG00000063531

Encoded Proteins

IDBP-135742

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170381:
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:14025276-14256689

Strand

Forward strand

Band

Transcripts

ENSMUST00000073957	ENSMUSP00000073612
ENSMUST00000130116

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030215	semaphorin receptor binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001953	negative regulation of cell-matrix adhesion
GO:0002040	sprouting angiogenesis
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0008360	regulation of cell shape
GO:0016525	negative regulation of angiogenesis
GO:0030154	cell differentiation
GO:0050808	synapse organization
GO:0071526	semaphorin-plexin signaling pathway
GO:2000249	regulation of actin cytoskeleton reorganization

Cellular Component

GO:0005576	extracellular region
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000170381

View Gene Order

ENSBTAG00000014920

Not yet available

Pathways

NETPATH

REACTOME

REACT_261444

Axon guidance pathway

REACT_188576

Developmental Biology pathway

REACT_263034

Semaphorin interactions pathway

REACT_231928

Other semaphorin interactions pathway

KEGG

mmu04360

Axon guidance pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19200

Other semaphorin interactions pathway

REACT_111045

Developmental Biology pathway

REACT_19271

Semaphorin interactions pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04360

Axon guidance pathway

INOH

PID NCI

plexind1_pathway

Plexin-D1 Signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.134093 Mm.415788

RefSeq

NM_011348

OMIM

CCDS

CCDS19093

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas