InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Perp

Summary

InnateDB Protein

IDBP-135764.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Perp

Protein Name

PERP, TP53 apoptosis effector

Synonyms

1110017A08Rik; KCP1; KRTCAP1; PIGPC1; THW;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019998

InnateDB Gene

IDBG-135762 (Perp)

Protein Structure

UniProt Annotation

Function

Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway. {ECO:0000269PubMed:10733530, ECO:0000269PubMed:15797384}.

Subcellular Localization

Cell junction, desmosome. Cell membrane; Multi-pass membrane protein. Note=Associated with desmosomes.

Disease Associations

Tissue Specificity

Expressed in the stratified squamous skin epithelium of the skin and the tongue, but not in simple epithelia (at protein level). Expressed in apoptotic cells. {ECO:0000269PubMed:10733530, ECO:0000269PubMed:15797384}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0002934	desmosome organization
GO:0034113	heterotypic cell-cell adhesion
GO:0045862	positive regulation of proteolysis
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097186	amelogenesis
GO:0097202	activation of cysteine-type endopeptidase activity

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030057	desmosome