Mus musculus Protein: Map4k2 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Protein | IDBP-135908.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | Map4k2 | ||||||||||||||||||||
Protein Name | mitogen-activated protein kinase kinase kinase kinase 2 | ||||||||||||||||||||
Synonyms | AI385662; BL44; GCK; Rab8ip; | ||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||
Ensembl Protein | ENSMUSP00000025897 | ||||||||||||||||||||
InnateDB Gene | IDBG-135906 (Map4k2) | ||||||||||||||||||||
Protein Structure | |||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||
Function | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN),or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. {ECO:0000269PubMed:19246396, ECO:0000269PubMed:8643544}. | ||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:8643544}. Basolateral cell membrane {ECO:0000269PubMed:8643544}; Peripheral membrane protein {ECO:0000269PubMed:8643544}. Golgi apparatus membrane {ECO:0000269PubMed:8643544}; Peripheral membrane protein {ECO:0000269PubMed:8643544}. | ||||||||||||||||||||
Disease Associations | |||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||
Comments | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||
PDB ID | MGI:1346883 | ||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001180 Citron-like IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF00780 PF07714 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||
SMART |
SM00036
SM00220 SM00219 |
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TIGRFAMs | |||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||
Modification | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | Q61161 | ||||||||||||||||||||
PhosphoSite | PhosphoSite-Q61161 | ||||||||||||||||||||
TrEMBL | |||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 26412 | ||||||||||||||||||||
UniGene | Mm.397983 | ||||||||||||||||||||
RefSeq | NP_033032 | ||||||||||||||||||||
MGI ID | |||||||||||||||||||||
MGI Symbol | Map4k2 | ||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | CCDS29503 | ||||||||||||||||||||
HPRD | |||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | AK051036 U50595 | ||||||||||||||||||||
GenPept | AAC52571 BAC34507 | ||||||||||||||||||||