Version 5.4
Mus musculus Protein: Fbxo25
Summary
InnateDB Protein IDBP-136121.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxo25
Protein Name F-box protein 25
Synonyms 9130015I06Rik; AI649137; Fbx25;
Species Mus musculus
Ensembl Protein ENSMUSP00000039544
InnateDB Gene IDBG-136117 (Fbxo25)
Protein Structure
UniProt Annotation
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT). {ECO:0000269PubMed:16714087, ECO:0000269PubMed:18287534}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16714087, ECO:0000269PubMed:18287534}. Note=In the nucleus, associates with a specific and novel subnuclear dot-like structure. Colocalized with SKP1.
Disease Associations
Tissue Specificity Expressded in all tissues tested, except striated muscle (at protein level). Expressed predominanltly in the cerebral cortex, the hippocampus and the Purkinje cell layer of the brain. Intestine and kidney show also significant levels. {ECO:0000269PubMed:16278047, ECO:0000269PubMed:16714087, ECO:0000269PubMed:18287534}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 110 interaction(s) predicted by orthology.
Predicted by orthology
Total 110 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0019005 SCF ubiquitin ligase complex
Protein Structure and Domains
PDB ID MGI:1914072
InterPro IPR001810 F-box domain
PFAM PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00256
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D2Y6
PhosphoSite PhosphoSite-Q9D2Y6
TrEMBL
UniProt Splice Variant
Entrez Gene 66822
UniGene Mm.396345
RefSeq NP_080061
MGI ID
MGI Symbol Fbxo25
OMIM
CCDS CCDS22118
HPRD
IMGT
EMBL AK008027 AK018626 BC014749
GenPept AAH14749 BAB25418 BAB31315

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca