InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hfe

Summary

InnateDB Protein

IDBP-136755.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hfe

Protein Name

hemochromatosis

Synonyms

MR2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089298

InnateDB Gene

IDBG-136751 (Hfe)

Protein Structure

UniProt Annotation

Function

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0042605	peptide antigen binding

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006955	immune response
GO:0007565	female pregnancy
GO:0010106	cellular response to iron ion starvation
GO:0019882	antigen processing and presentation
GO:0042446	hormone biosynthetic process
GO:0055072	iron ion homeostasis
GO:0060586	multicellular organismal iron ion homeostasis
GO:0097459	iron ion import into cell

Cellular Component

GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle
GO:0042612	MHC class I protein complex
GO:0045177	apical part of cell
GO:0045178	basal part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome

Protein Structure and Domains

PDB ID

MGI:109191

InterPro

IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR011162 MHC classes I/II-like antigen recognition protein
IPR027648 MHC class I alpha chain

PFAM

PF00129
PF07654

PRINTS

PR01638

PIRSF

SMART

SM00407

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt