InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hfe

Summary

InnateDB Gene

IDBG-136751.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hfe

Gene Name

hemochromatosis

Synonyms

MR2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000006611

Encoded Proteins

IDBP-136755

hemochromatosis

IDBP-136757

hemochromatosis

IDBP-136759

hemochromatosis

IDBP-538376

hemochromatosis

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000010704:
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:23702034-23710854

Strand

Reverse strand

Band

A3.1

Transcripts

ENSMUST00000091706	ENSMUSP00000089298
ENSMUST00000091707	ENSMUSP00000089299
ENSMUST00000006787	ENSMUSP00000006787
ENSMUST00000151243	ENSMUSP00000116569

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0042605	peptide antigen binding

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006955	immune response
GO:0007565	female pregnancy
GO:0010106	cellular response to iron ion starvation
GO:0019882	antigen processing and presentation
GO:0042446	hormone biosynthetic process
GO:0055072	iron ion homeostasis
GO:0060586	multicellular organismal iron ion homeostasis
GO:0097459	iron ion import into cell

Cellular Component

GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle
GO:0042612	MHC class I protein complex
GO:0045177	apical part of cell
GO:0045178	basal part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000010704

View Gene Order

ENSBTAG00000013065

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.2681 Mm.408066 Mm.487725

RefSeq

NM_010424

OMIM

CCDS

CCDS26360

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas