InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myst4

Summary

InnateDB Protein

IDBP-137190.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myst4

Protein Name

MYST histone acetyltransferase monocytic leukemia 4

Synonyms

AI507552; B130044K16Rik; mKIAA0383; Morf; MYST-4; Myst4; qkf; querkopf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066693

InnateDB Gene

IDBG-137188 (Myst4)

Protein Structure

UniProt Annotation

Function

Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity). Involved in cerebral cortex development. {ECO:0000250, ECO:0000269PubMed:10821753}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:10821753}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016407	acetyltransferase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

Biological Process

GO:0006334	nucleosome assembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016573	histone acetylation
GO:0043966	histone H3 acetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0000786	nucleosome
GO:0005634	nucleus
GO:0070776	MOZ/MORF histone acetyltransferase complex

Protein Structure and Domains

PDB ID

MGI:1858746

InterPro

IPR001965 Zinc finger, PHD-type
IPR002717 MOZ/SAS-like protein
IPR005818 Linker histone H1/H5, domain H15
IPR011011 Zinc finger, FYVE/PHD-type
IPR016181 Acyl-CoA N-acyltransferase
IPR019787 Zinc finger, PHD-finger

PFAM

PF01853
PF00538
PF00628

PRINTS

PIRSF

SMART

SM00249
SM00526

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BRB7