InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Angpt2

Summary

InnateDB Protein

IDBP-137358.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Angpt2

Protein Name

angiopoietin 2

Synonyms

Agpt2; Ang-2; Ang2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033846

InnateDB Gene

IDBG-137356 (Angpt2)

Protein Structure

UniProt Annotation

Function

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed only at sites of vascular remodeling.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005172	vascular endothelial growth factor receptor binding
GO:0005515	protein binding
GO:0030971	receptor tyrosine kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0001974	blood vessel remodeling
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007281	germ cell development
GO:0007492	endoderm development
GO:0009314	response to radiation
GO:0009612	response to mechanical stimulus
GO:0009749	response to glucose
GO:0010812	negative regulation of cell-substrate adhesion
GO:0014070	response to organic cyclic compound
GO:0014823	response to activity
GO:0016525	negative regulation of angiogenesis
GO:0030097	hemopoiesis
GO:0031100	organ regeneration
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0045765	regulation of angiogenesis
GO:0045766	positive regulation of angiogenesis
GO:0048014	Tie signaling pathway
GO:0048514	blood vessel morphogenesis
GO:0050928	negative regulation of positive chemotaxis
GO:0060135	maternal process involved in female pregnancy
GO:0071363	cellular response to growth factor stimulus
GO:0072012	glomerulus vasculature development