InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plcb3

Summary

InnateDB Protein

IDBP-137390.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plcb3

Protein Name

phospholipase C, beta 3

Synonyms

mKIAA4098;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025912

InnateDB Gene

IDBG-137388 (Plcb3)

Protein Structure

UniProt Annotation

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9714794}.

Disease Associations

Tissue Specificity

Highly expressed in kidney, skeletal muscle, liver, lung, heart and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0003073	regulation of systemic arterial blood pressure
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005634	nucleus
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:104778

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR009535 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site
IPR014815 PLC-beta, C-terminal
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM

PF00168
PF00388
PF00387
PF06631
PF08703
PF09279

PRINTS

PR00360
PR00390

PIRSF

PIRSF000956

SMART

SM00239
SM00148
SM00149

TIGRFAMs

Post-translational Modifications

Modification

Cross-References