InnateDB Protein
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IDBP-137899.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rspo2
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Protein Name
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R-spondin 2 homolog (Xenopus laevis)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000067325
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InnateDB Gene
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IDBG-137897 (Rspo2)
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Protein Structure
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Function |
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. {ECO:0000269PubMed:21693646}.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:16543246}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1922667
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InterPro |
IPR000884
Thrombospondin, type 1 repeat
IPR006212
Furin-like repeat
IPR009030
Insulin-like growth factor binding protein, N-terminal
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PFAM |
PF00090
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PRINTS |
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PIRSF |
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SMART |
SM00209
SM00261
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BFU0
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PhosphoSite |
PhosphoSite-Q8BFU0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
239405
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UniGene |
Mm.401211
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RefSeq |
NP_766403
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MGI ID |
4C99
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MGI Symbol |
Rspo2
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OMIM |
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CCDS |
CCDS27451
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HPRD |
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IMGT |
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EMBL |
AK049891
AK087485
BC052844
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GenPept |
BAC33974
BAC39893
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