InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLR2E

Summary

InnateDB Protein

IDBP-13795.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLR2E

Protein Name

polymerase (RNA) II (DNA directed) polypeptide E, 25kDa

Synonyms

hRPB25; hsRPB5; RPABC1; RPB5; XAP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000215587

InnateDB Gene

IDBG-13793 (POLR2E)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9852112}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 109 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	109 [view]
Protein-Protein	106 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001054	RNA polymerase I activity
GO:0001055	RNA polymerase II activity
GO:0001056	RNA polymerase III activity
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0005515	protein binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006351	transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0006383	transcription from RNA polymerase III promoter
GO:0006385	transcription elongation from RNA polymerase III promoter
GO:0006386	termination of RNA polymerase III transcription
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016032	viral process
GO:0032481	positive regulation of type I interferon production
GO:0045087	innate immune response
GO:0050434	positive regulation of viral transcription

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005665	DNA-directed RNA polymerase II, core complex
GO:0005666	DNA-directed RNA polymerase III complex
GO:0005736	DNA-directed RNA polymerase I complex
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000783 RNA polymerase, subunit H/Rpb5 C-terminal
IPR005571 RNA polymerase, Rpb5, N-terminal
IPR014381 DNA-directed RNA polymerase RPB5 subunit, eukaryote/virus

PFAM

PF01191
PF03871

PRINTS

PIRSF

PIRSF000747

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P19388