InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnni3

Summary

InnateDB Protein

IDBP-138201.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnni3

Protein Name

troponin I, cardiac 3

Synonyms

cTnI; Tn1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096458

InnateDB Gene

IDBG-138199 (Tnni3)

Protein Structure

UniProt Annotation

Function

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0019855	calcium channel inhibitor activity
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0030172	troponin C binding
GO:0031014	troponin T binding
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001570	vasculogenesis
GO:0001980	regulation of systemic arterial blood pressure by ischemic conditions
GO:0006874	cellular calcium ion homeostasis
GO:0006937	regulation of muscle contraction
GO:0006940	regulation of smooth muscle contraction
GO:0006941	striated muscle contraction
GO:0007507	heart development
GO:0032780	negative regulation of ATPase activity
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060047	heart contraction
GO:0060048	cardiac muscle contraction