Version 5.4
Mus musculus Gene: Tnni3
Summary
InnateDB Gene IDBG-138199.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnni3
Gene Name troponin I, cardiac 3
Synonyms cTnI; Tn1
Species Mus musculus
Ensembl Gene ENSMUSG00000035458
Encoded Proteins
IDBP-138201
troponin I, cardiac 3
IDBP-536711
troponin I, cardiac 3
IDBP-533399
troponin I, cardiac 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129991:
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:4518305-4524229
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000098859 ENSMUSP00000096458
ENSMUST00000132621
ENSMUST00000126873
ENSMUST00000140424 ENSMUSP00000115015
ENSMUST00000154913 ENSMUSP00000122916
ENSMUST00000127736
ENSMUST00000150166
ENSMUST00000151844
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019855 calcium channel inhibitor activity
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030172 troponin C binding
GO:0031014 troponin T binding
GO:0046872 metal ion binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001570 vasculogenesis
GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions
GO:0006874 cellular calcium ion homeostasis
GO:0006937 regulation of muscle contraction
GO:0006940 regulation of smooth muscle contraction
GO:0006941 striated muscle contraction
GO:0007507 heart development
GO:0032780 negative regulation of ATPase activity
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005737 cytoplasm
GO:0005861 troponin complex
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0043292 contractile fiber
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000129991
View Gene Order
ENSBTAG00000006424
Not yet available
Pathways
NETPATH
REACTOME
REACT_232053
Striated Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
KEGG
mmu04260
Cardiac muscle contraction pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
REACT_213099
Muscle contraction pathway
REACT_223821
Striated Muscle Contraction pathway
KEGG
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_009406
OMIM
CCDS CCDS39736
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca