InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: S1pr2

Summary

InnateDB Protein

IDBP-138521.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S1pr2

Protein Name

sphingosine-1-phosphate receptor 2

Synonyms

1100001A16Rik; Edg5; Gpcr13; H218; LPb2; S1P2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053394

InnateDB Gene

IDBG-138519 (S1pr2)

Protein Structure

UniProt Annotation

Function

Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Most abundant in heart and lung; low, but clearly observed in kidney, liver and thymus; much lower but detectable in brain, testis, stomach and intestine. Not significantly detected in any of the sections of embryonic day (E) 14-18, except in embryonic brain. {ECO:0000269PubMed:9931453}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0004930	G-protein coupled receptor activity
GO:0005178	integrin binding
GO:0038036	sphingosine-1-phosphate receptor activity

Biological Process

GO:0003376	sphingosine-1-phosphate signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0090394	negative regulation of excitatory postsynaptic membrane potential
GO:1903142	positive regulation of establishment of endothelial barrier

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:99569

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001671 Melanocortin/ACTH receptor
IPR004061 Sphingosine 1-phosphate receptor
IPR004063 EDG-5 sphingosine 1-phosphate receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00534
PR01523
PR01525

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P52592