InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd14

Summary

InnateDB Protein

IDBP-138527.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd14

Protein Name

CD14 antigen

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056669

InnateDB Gene

IDBG-138525 (Cd14)

Protein Structure

UniProt Annotation

Function

In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0005515	protein binding
GO:0070891	lipoteichoic acid binding

Biological Process

GO:0002237	response to molecule of bacterial origin
GO:0006954	inflammatory response
GO:0009408	response to heat
GO:0032026	response to magnesium ion
GO:0032496	response to lipopolysaccharide
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034612	response to tumor necrosis factor
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045807	positive regulation of endocytosis
GO:0050715	positive regulation of cytokine secretion
GO:0051602	response to electrical stimulus
GO:0071222	cellular response to lipopolysaccharide
GO:0071223	cellular response to lipoteichoic acid

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031225	anchored component of membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome