InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: XPO4

Summary

InnateDB Protein

IDBP-13862.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XPO4

Protein Name

exportin 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000255305

InnateDB Gene

IDBG-13860 (XPO4)

Protein Structure

UniProt Annotation

Function

Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269PubMed:10944119, ECO:0000269PubMed:16449645}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16449645}. Nucleus {ECO:0000269PubMed:16449645}. Note=Shuttles between the nucleus and the cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.