Version 5.4
Mus musculus Protein: Icam5
Summary
InnateDB Protein IDBP-138762.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Icam5
Protein Name intercellular adhesion molecule 5, telencephalin
Synonyms CD50; ICAM-3; Icam3; Tlcn; TLN;
Species Mus musculus
Ensembl Protein ENSMUSP00000019616
InnateDB Gene IDBG-138760 (Icam5)
Protein Structure
UniProt Annotation
Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). {ECO:0000269PubMed:7794412}.
Subcellular Localization Membrane {ECO:0000269PubMed:7794412}; Single-pass type I membrane protein {ECO:0000269PubMed:7794412}.
Disease Associations
Tissue Specificity Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon. {ECO:0000269PubMed:7794412}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006909 phagocytosis
GO:0016337 single organismal cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:109430
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
IPR003988 Intercellular adhesion molecule
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013768 Intercellular adhesion molecule, N-terminal
PFAM PF07679
PF03921
PRINTS PR01472
PR01473
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60625
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 15898
UniGene Mm.4629
RefSeq NP_032345
MGI ID
MGI Symbol Icam5
OMIM
CCDS CCDS22891
HPRD
IMGT
EMBL AC159314 AK135040 BC113140 CH466522 U06483 U89893
GenPept AAA67204 AAC53308 AAI13141 BAE22394 EDL25153

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca