Version 5.4
Mus musculus Gene: Icam5
Summary
InnateDB Gene IDBG-138760.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Icam5
Gene Name intercellular adhesion molecule 5, telencephalin
Synonyms CD50; ICAM-3; Icam3; Tlcn; TLN
Species Mus musculus
Ensembl Gene ENSMUSG00000032174
Encoded Proteins
IDBP-138762
intercellular adhesion molecule 5, telencephalin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105376:
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:21032038-21039036
Strand Forward strand
Band A3
Transcripts
ENSMUST00000019616 ENSMUSP00000019616
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006909 phagocytosis
GO:0016337 single organismal cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105376
View Gene Order
ENSBTAG00000010316
Not yet available
Cross-References
SwissProt Q60625
TrEMBL
UniProt Splice Variant
Entrez Gene 15898
UniGene Mm.4629
RefSeq NM_008319
OMIM
CCDS CCDS22891
HPRD
IMGT
MGI ID MGI:109430
MGI Symbol Icam5
EMBL AC159314 AK135040 BC113140 CH466522 U06483 U89893
GenPept AAA67204 AAC53308 AAI13141 BAE22394 EDL25153
RNA Seq Atlas 15898

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca