InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccna2

Summary

InnateDB Protein

IDBP-138778.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccna2

Protein Name

cyclin A2

Synonyms

AA408589; Ccn-1; Ccn1; Ccna; Cyca; CycA2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029270

InnateDB Gene

IDBG-138776 (Ccna2)

Protein Structure

UniProt Annotation

Function

Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions. {ECO:0000269PubMed:10068472}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. In the testis, expressed in germ cells and in the ovary, in both germline and somatic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	75 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007067	mitotic nuclear division
GO:0007265	Ras protein signal transduction
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0031100	organ regeneration
GO:0032355	response to estradiol
GO:0033762	response to glucagon
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048146	positive regulation of fibroblast proliferation
GO:0051726	regulation of cell cycle