InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRDM9

Summary

InnateDB Protein

IDBP-13914.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDM9

Protein Name

PR domain containing 9

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296682

InnateDB Gene

IDBG-13910 (PRDM9)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0010844	recombination hotspot binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006311	meiotic gene conversion
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0010845	positive regulation of reciprocal meiotic recombination
GO:0016571	histone methylation
GO:0034968	histone lysine methylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051568	histone H3-K4 methylation
GO:0060903	positive regulation of meiosis I

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome

Protein Structure and Domains

PDB ID

InterPro

IPR001214 SET domain
IPR001909 Krueppel-associated box
IPR003655 Krueppel-associated box-related
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR019041 SSXRD motif

PFAM

PF00856
PF01352
PF00096
PF09514

PRINTS

PIRSF

SMART

SM00317
SM00349
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NQV7