InnateDB Protein
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IDBP-139917.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pip4k2a
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Protein Name
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phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
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Synonyms
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AW742916; Pip5k2a;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000006912
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InnateDB Gene
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IDBG-139915 (Pip4k2a)
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Protein Structure
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Function |
Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P (By similarity). May be involved in thrombopoiesis and the terminal maturation of megakaryocytes and regulation of their size. {ECO:0000250, ECO:0000269PubMed:16434494}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm. Cell membrane. Note=Localization to the nucleus is modulated by the interaction with PIP4K2B (By similarity). Localized to the demarcation membrane system (DMS). May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Detected in rod photoreceptor cells. {ECO:0000269PubMed:20204506}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005524
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ATP binding
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GO:0016307
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phosphatidylinositol phosphate kinase activity
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GO:0016309
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1-phosphatidylinositol-5-phosphate 4-kinase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1298206
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InterPro |
IPR002498
Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034
Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
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PFAM |
PF01504
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PRINTS |
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PIRSF |
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SMART |
SM00330
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TIGRFAMs |
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Modification |
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SwissProt |
O70172
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PhosphoSite |
PhosphoSite-O70172
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TrEMBL |
Q544E3
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UniProt Splice Variant |
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Entrez Gene |
18718
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UniGene |
Mm.313977
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RefSeq |
NP_032871
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MGI ID |
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MGI Symbol |
Pip4k2a
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OMIM |
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CCDS |
CCDS15712
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HPRD |
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IMGT |
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EMBL |
AB009615
AK040558
BC011097
CH466542
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GenPept |
AAH11097
BAA25676
BAC30626
EDL08108
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