Version 5.4
Mus musculus Protein: Vps36
Summary
InnateDB Protein IDBP-140067.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vps36
Protein Name vacuolar protein sorting 36 (yeast)
Synonyms 1700010A24Rik; 2210415M20Rik; 2810408E15Rik; Eap45;
Species Mus musculus
Ensembl Protein ENSMUSP00000033866
InnateDB Gene IDBG-140065 (Vps36)
Protein Structure
UniProt Annotation
Function Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}. Late endosome {ECO:0000250}. Membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0043130 ubiquitin binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0015031 protein transport
GO:0016197 endosomal transport
Cellular Component
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005768 endosome
GO:0005770 late endosome
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1917410
InterPro IPR007286 EAP30
IPR021648 Vacuolar protein sorting protein 36, GLUE domain
PFAM PF04157
PF11605
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91XD6
PhosphoSite PhosphoSite-Q91XD6
TrEMBL Q3UBB2
UniProt Splice Variant
Entrez Gene 70160
UniGene Mm.474298
RefSeq NP_081614
MGI ID 2DX5
MGI Symbol Vps36
OMIM
CCDS CCDS22171
HPRD
IMGT
EMBL AK008946 AK150754 AK151035 AK161865 BC010811 CH466580
GenPept AAH10811 BAB25984 BAE29824 BAE30052 BAE36614 EDL32902

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca