InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD27

Summary

InnateDB Protein

IDBP-14016.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD27

Protein Name

CD27 molecule

Synonyms

S152; S152. LPFS2; T14; TNFRSF7; Tp55;

Species

Homo sapiens

Ensembl Protein

ENSP00000266557

InnateDB Gene

IDBG-14014 (CD27)

Protein Structure

UniProt Annotation

Function

Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Lymphoproliferative syndrome 2 (LPFS2) [MIM:615122]: An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation. {ECO:0000269PubMed:22197273, ECO:0000269PubMed:22801960}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Found in most T-lymphocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0008588	release of cytoplasmic sequestered NF-kappaB
GO:0016064	immunoglobulin mediated immune response
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045579	positive regulation of B cell differentiation
GO:0046330	positive regulation of JNK cascade
GO:0070233	negative regulation of T cell apoptotic process
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome