InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD27

Summary

InnateDB Gene

IDBG-14014.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD27

Gene Name

CD27 molecule

Synonyms

S152; S152. LPFS2; T14; TNFRSF7; Tp55

Species

Homo sapiens

Ensembl Gene

ENSG00000139193

Encoded Proteins

IDBP-14016

CD27 molecule

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 9582383

CD27 is a member of the tumour necrosis factor receptor superfamily that activates NF-kappaB and MAPK9 (stress-activated protein kinase/c-Jun N-terminal kinase) via TRAF2, TRAF5 and MAP3K14 (NIK).

Entrez Gene

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:6444867-6451718

Strand

Forward strand

Band

p13.31

Transcripts

ENST00000266557	ENSP00000266557
ENST00000541233

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0008588	release of cytoplasmic sequestered NF-kappaB
GO:0016064	immunoglobulin mediated immune response
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045579	positive regulation of B cell differentiation
GO:0046330	positive regulation of JNK cascade
GO:0070233	negative regulation of T cell apoptotic process
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030336

View Gene Order

ENSBTAG00000014725

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P26842

TrEMBL

UniProt Splice Variant

Entrez Gene

939

UniGene

Hs.355307

RefSeq

NM_001242

HUGO

HGNC:11922

OMIM

186711

CCDS

CCDS8545

HPRD

01723

IMGT

EMBL

AC005840 AK315732 AY504961 BC012160 M63928

GenPept

AAA58411 AAH12160 AAR84239 BAG38087

RNA Seq Atlas

939