Homo sapiens Gene: CD27
Summary
InnateDB Gene IDBG-14014.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD27
Gene Name CD27 molecule
Synonyms S152; S152. LPFS2; T14; TNFRSF7; Tp55;
Species Homo sapiens
Ensembl Gene ENSG00000139193
Encoded Proteins
CD27 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CD27 is a member of the tumour necrosis factor receptor superfamily that activates NF-kappaB and MAPK9 (stress-activated protein kinase/c-Jun N-terminal kinase) via TRAF2, TRAF5 and MAP3K14 (NIK).
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:6444867-6451718
Strand Forward strand
Band p13.31
Transcripts
ENST00000266557 ENSP00000266557
ENST00000541233
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0008588 release of cytoplasmic sequestered NF-kappaB
GO:0016064 immunoglobulin mediated immune response
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0045579 positive regulation of B cell differentiation
GO:0046330 positive regulation of JNK cascade
GO:0070233 negative regulation of T cell apoptotic process
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P26842
TrEMBL
UniProt Splice Variant
Entrez Gene 939
UniGene Hs.355307
RefSeq NM_001242
HUGO HGNC:11922
OMIM 186711
CCDS CCDS8545
HPRD 01723
IMGT
EMBL AC005840 AK315732 AY504961 BC012160 M63928
GenPept AAA58411 AAH12160 AAR84239 BAG38087
RNA Seq Atlas 939