|Homo sapiens Gene: CD27|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||CD27 molecule|
|Synonyms||S152; S152. LPFS2; T14; TNFRSF7; Tp55;|
|Useful resources||Stemformatics EHFPI ImmGen|
CD27 is a member of the tumour necrosis factor receptor superfamily that activates NF-kappaB and MAPK9 (stress-activated protein kinase/c-Jun N-terminal kinase) via TRAF2, TRAF5 and MAP3K14 (NIK).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 12:6444867-6451718|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Cytokine-cytokine receptor interaction pathway
|UniProt Splice Variant|
|EMBL||AC005840 AK315732 AY504961 BC012160 M63928|
|GenPept||AAA58411 AAH12160 AAR84239 BAG38087|
|RNA Seq Atlas||939|