InnateDB Protein
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IDBP-1404.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ESCO1
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Protein Name
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establishment of cohesion 1 homolog 1 (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000372763
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InnateDB Gene
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IDBG-1402 (ESCO1)
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Protein Structure
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Function |
Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3. {ECO:0000269PubMed:14576321, ECO:0000269PubMed:15958495, ECO:0000269PubMed:18614053, ECO:0000269PubMed:19907496}.
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Subcellular Localization |
Nucleus. Chromosome. Note=Nuclear at interphase, associated with chromosomes during mitosis.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle. {ECO:0000269PubMed:14576321}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0016746
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transferase activity, transferring acyl groups
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5FWF5
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PhosphoSite |
PhosphoSite-Q5FWF5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
114799
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UniGene |
Hs.621074
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RefSeq |
XP_006722442
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HUGO |
HGNC:24645
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OMIM |
609674
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CCDS |
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HPRD |
16868
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IMGT |
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EMBL |
AB067498
AK090579
AL832041
AL834200
BC036943
BC089426
BK001617
CH471088
EF444976
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GenPept |
AAH36943
AAH89426
ACA05989
ACA05990
BAB67804
BAC03483
CAH10584
CAH10682
DAA02068
EAX01127
EAX01128
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