InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ESCO1

Summary

InnateDB Protein

IDBP-1406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ESCO1

Protein Name

establishment of cohesion 1 homolog 1 (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000269214

InnateDB Gene

IDBG-1402 (ESCO1)

Protein Structure

UniProt Annotation

Function

Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3. {ECO:0000269PubMed:14576321, ECO:0000269PubMed:15958495, ECO:0000269PubMed:18614053, ECO:0000269PubMed:19907496}.

Subcellular Localization

Nucleus. Chromosome. Note=Nuclear at interphase, associated with chromosomes during mitosis.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle. {ECO:0000269PubMed:14576321}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016746	transferase activity, transferring acyl groups
GO:0046872	metal ion binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006275	regulation of DNA replication
GO:0007062	sister chromatid cohesion
GO:0034421	post-translational protein acetylation