InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Appl1

Summary

InnateDB Protein

IDBP-140681.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Appl1

Protein Name

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

Synonyms

2900057D21Rik; 7330406P05Rik; AI585782; AW209077; BB022931; C88264; DIP13;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042875

InnateDB Gene

IDBG-140679 (Appl1)

Protein Structure

UniProt Annotation

Function

Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction (By similarity). {ECO:0000250}.

Subcellular Localization

Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043422	protein kinase B binding

Biological Process

GO:0007049	cell cycle
GO:0008283	cell proliferation
GO:0046324	regulation of glucose import
GO:0090003	regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0012506	vesicle membrane
GO:0016581	NuRD complex
GO:0031901	early endosome membrane
GO:0070062	extracellular vesicular exosome