InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Diap1

Summary

InnateDB Protein

IDBP-140705.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Diap1

Protein Name

diaphanous homolog 1 (Drosophila)

Synonyms

D18Wsu154e; Dia1; Diaph1; Drf1; mKIAA4062; p140mDia;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025337

InnateDB Gene

IDBG-140703 (Diap1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0017048	Rho GTPase binding
GO:0044325	ion channel binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0016043	cellular component organization
GO:0030036	actin cytoskeleton organization
GO:0030041	actin filament polymerization
GO:0030335	positive regulation of cell migration
GO:0032886	regulation of microtubule-based process
GO:0035372	protein localization to microtubule
GO:0051279	regulation of release of sequestered calcium ion into cytosol
GO:0071420	cellular response to histamine

Cellular Component

GO:0032587	ruffle membrane
GO:0072686	mitotic spindle

Protein Structure and Domains

PDB ID

MGI:1194490

InterPro

IPR009408 Formin Homology 1
IPR010465 DRF autoregulatory
IPR010472 Formin, FH3 domain
IPR010473 Formin, GTPase-binding domain
IPR015425 Formin, FH2 domain
IPR016024 Armadillo-type fold

PFAM

PF06346
PF06345
PF06367
PF06371
PF02181

PRINTS

PIRSF

SMART

SM00498

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite