InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAPK8IP2

Summary

InnateDB Protein

IDBP-14074.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPK8IP2

Protein Name

mitogen-activated protein kinase 8 interacting protein 2

Synonyms

IB-2; IB2; JIP2; PRKM8IPL;

Species

Homo sapiens

Ensembl Protein

ENSP00000008876

InnateDB Gene

IDBG-14068 (MAPK8IP2)

Protein Structure

UniProt Annotation

Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Note=Accumulates in cell surface projections.

Disease Associations

Tissue Specificity

Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland and salivary gland.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	95 [view]
Protein-Protein	93 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005078	MAP-kinase scaffold activity
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0019894	kinesin binding
GO:0019901	protein kinase binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0000165	MAPK cascade
GO:0001662	behavioral fear response
GO:0007172	signal complex assembly
GO:0009967	positive regulation of signal transduction
GO:0010469	regulation of receptor activity
GO:0035176	social behavior
GO:0045860	positive regulation of protein kinase activity
GO:0046328	regulation of JNK cascade
GO:0046958	nonassociative learning
GO:0048813	dendrite morphogenesis
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity