Version 5.4
Mus musculus Protein: Arhgef3
Summary
InnateDB Protein IDBP-140982.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef3
Protein Name Rho guanine nucleotide exchange factor (GEF) 3
Synonyms 1200004I24Rik; 9830169H03Rik; C76747; Xpln;
Species Mus musculus
Ensembl Protein ENSMUSP00000046486
InnateDB Gene IDBG-140980 (Arhgef3)
Protein Structure
UniProt Annotation
Function Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. {ECO:0000269PubMed:11839749}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11839749}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Biological Process
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1918954
InterPro IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
PFAM PF00621
PF00169
PRINTS
PIRSF
SMART SM00325
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91X46
PhosphoSite PhosphoSite-Q91X46
TrEMBL
UniProt Splice Variant
Entrez Gene 71704
UniGene
RefSeq NP_082147
MGI ID 2Z0Q
MGI Symbol Arhgef3
OMIM
CCDS CCDS26886
HPRD
IMGT
EMBL AK004600 AK029872 BC005517 BC007153 BC012262
GenPept AAH05517 AAH07153 AAH12262 BAB23401 BAC26652

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca