Version 5.4
| Mus musculus Gene: Arhgef3 | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-140980.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Arhgef3 | ||||||
| Gene Name | Rho guanine nucleotide exchange factor (GEF) 3 | ||||||
| Synonyms | 1200004I24Rik; 9830169H03Rik; C76747; Xpln | ||||||
| Species | Mus musculus | ||||||
| Ensembl Gene | ENSMUSG00000021895 | ||||||
| Encoded Proteins |
Rho guanine nucleotide exchange factor (GEF) 3
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163947:
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 14:27238039-27403904 | ||||||
| Strand | Forward strand | ||||||
| Band | A3 | ||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||
| NETPATH | |||||||
| REACTOME |
GPCR downstream signaling pathway
Signaling by GPCR pathway
NRAGE signals death through JNK pathway
Signaling by Rho GTPases pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Signalling by NGF pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
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| KEGG | |||||||
| INOH | |||||||
| PID NCI | |||||||
| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH | |||||||
| REACTOME |
NRAGE signals death through JNK pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Signalling by NGF pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
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| KEGG | |||||||
| INOH | |||||||
| PID NCI |
Regulation of RhoA activity
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| Cross-References | |||||||
| SwissProt | Q91X46 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 71704 | ||||||
| UniGene | |||||||
| RefSeq | NM_001289686 NM_001289687 NM_001289688 NM_027871 XM_006519571 XM_006519572 XM_006519573 XM_006519574 XM_006519575 XM_006519576 XM_006519579 XM_006519580 | ||||||
| OMIM | |||||||
| CCDS | CCDS26886 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| MGI ID | MGI:1918954 | ||||||
| MGI Symbol | Arhgef3 | ||||||
| EMBL | AK004600 AK029872 BC005517 BC007153 BC012262 | ||||||
| GenPept | AAH05517 AAH07153 AAH12262 BAB23401 BAC26652 | ||||||
| RNA Seq Atlas | 71704 | ||||||