InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNW1

Summary

InnateDB Protein

IDBP-14102.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNW1

Protein Name

SNW domain containing 1

Synonyms

Bx42; NCOA-62; Prp45; PRPF45; SKIIP; SKIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000261531

InnateDB Gene

IDBG-14100 (SNW1)

Protein Structure

UniProt Annotation

Function

Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probbaly involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269PubMed:10644367, ECO:0000269PubMed:11278756, ECO:0000269PubMed:11371506, ECO:0000269PubMed:11514567, ECO:0000269PubMed:12840015, ECO:0000269PubMed:14985122, ECO:0000269PubMed:15194481, ECO:0000269PubMed:15905409, ECO:0000269PubMed:18794151, ECO:0000269PubMed:19818711, ECO:0000269PubMed:21245387, ECO:0000269PubMed:21460037, ECO:0000269PubMed:9632709}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12840015}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 148 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	148 [view]
Protein-Protein	134 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	12 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005112	Notch binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0035257	nuclear hormone receptor binding
GO:0042809	vitamin D receptor binding
GO:0042974	retinoic acid receptor binding
GO:0044822	poly(A) RNA binding
GO:0046332	SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000398	mRNA splicing, via spliceosome
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0007219	Notch signaling pathway
GO:0010467	gene expression
GO:0016032	viral process
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043923	positive regulation by host of viral transcription
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048026	positive regulation of mRNA splicing, via spliceosome
GO:0048384	retinoic acid receptor signaling pathway
GO:0048385	regulation of retinoic acid receptor signaling pathway
GO:0050769	positive regulation of neurogenesis
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0070562	regulation of vitamin D receptor signaling pathway
GO:0070564	positive regulation of vitamin D receptor signaling pathway
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0008024	positive transcription elongation factor complex b
GO:0016363	nuclear matrix
GO:0071013	catalytic step 2 spliceosome
GO:0071146	SMAD3-SMAD4 protein complex