InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SNW1

Summary

InnateDB Gene

IDBG-14100.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNW1

Gene Name

SNW domain containing 1

Synonyms

Bx42; NCOA-62; Prp45; PRPF45; SKIIP; SKIP

Species

Homo sapiens

Ensembl Gene

ENSG00000100603

Encoded Proteins

IDBP-14102

SNW domain containing 1

IDBP-594380

SNW domain containing 1

IDBP-602470

SNW domain containing 1

IDBP-588956

SNW domain containing 1

IDBP-586887

SNW domain containing 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:77717599-77761207

Strand

Reverse strand

Band

q24.3

Transcripts

ENST00000261531	ENSP00000261531
ENST00000554775	ENSP00000452059
ENST00000556428	ENSP00000451741
ENST00000555761	ENSP00000451129
ENST00000553565
ENST00000554324	ENSP00000452473
ENST00000557663

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 148 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	148 [view]
Protein-Protein	134 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	12 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005112	Notch binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0035257	nuclear hormone receptor binding
GO:0042809	vitamin D receptor binding
GO:0042974	retinoic acid receptor binding
GO:0044822	poly(A) RNA binding
GO:0046332	SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000398	mRNA splicing, via spliceosome
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0007219	Notch signaling pathway
GO:0010467	gene expression
GO:0016032	viral process
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043923	positive regulation by host of viral transcription
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048026	positive regulation of mRNA splicing, via spliceosome
GO:0048384	retinoic acid receptor signaling pathway
GO:0048385	regulation of retinoic acid receptor signaling pathway
GO:0050769	positive regulation of neurogenesis
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0070562	regulation of vitamin D receptor signaling pathway
GO:0070564	positive regulation of vitamin D receptor signaling pathway
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0008024	positive transcription elongation factor complex b
GO:0016363	nuclear matrix
GO:0071013	catalytic step 2 spliceosome
GO:0071146	SMAD3-SMAD4 protein complex