InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dusp18

Summary

InnateDB Protein

IDBP-141156.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dusp18

Protein Name

dual specificity phosphatase 18

Synonyms

4930527G07Rik; AI430870; BB028064; DSP18; DUSP20; LMWDSP20;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057346

InnateDB Gene

IDBG-141154 (Dusp18)

Protein Structure

UniProt Annotation

Function

Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18385140}. Nucleus {ECO:0000250}. Mitochondrion inner membrane {ECO:0000269PubMed:18385140}; Peripheral membrane protein {ECO:0000269PubMed:18385140}; Intermembrane side {ECO:0000269PubMed:18385140}. Note=Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0006470	protein dephosphorylation
GO:0006612	protein targeting to membrane
GO:0006626	protein targeting to mitochondrion
GO:0016311	dephosphorylation
GO:0033365	protein localization to organelle
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0046677	response to antibiotic

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0031304	intrinsic to mitochondrial inner membrane
GO:0031314	extrinsic component of mitochondrial inner membrane

Protein Structure and Domains

PDB ID

MGI:1922469

InterPro

IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR020417 Atypical dual specificity phosphatase
IPR020420 Atypical dual specificity phosphatase, subfamily B
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00782

PRINTS

PR01908
PR01910

PIRSF

SMART

SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt