InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SAP18

Summary

InnateDB Protein

IDBP-14137.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAP18

Protein Name

Sin3A-associated protein, 18kDa

Synonyms

2HOR0202; SAP18P;

Species

Homo sapiens

Ensembl Protein

ENSP00000371973

InnateDB Gene

IDBG-14135 (SAP18)

Protein Structure

UniProt Annotation

Function

Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. {ECO:0000269PubMed:12665594, ECO:0000269PubMed:20966198, ECO:0000269PubMed:22203037, ECO:0000269PubMed:9150135}.

Subcellular Localization

Nucleus. Cytoplasm. Nucleus speckle. Note=Shuttles between the nucleus and the cytoplasm. Colocalizes with ACIN1 and SRSF2 in nuclear speckles.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.

Experimentally validated
Total	111 [view]
Protein-Protein	101 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	7 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0043065	positive regulation of apoptotic process
GO:0048025	negative regulation of mRNA splicing, via spliceosome

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016607	nuclear speck
GO:0035145	exon-exon junction complex
GO:0061574	ASAP complex