Homo sapiens Gene: SAP18
Summary
InnateDB Gene IDBG-14135.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAP18
Gene Name Sin3A-associated protein, 18kDa
Synonyms 2HOR0202; SAP18P;
Species Homo sapiens
Ensembl Gene ENSG00000150459
Encoded Proteins
Sin3A-associated protein, 18kDa
Sin3A-associated protein, 18kDa
Sin3A-associated protein, 18kDa
Sin3A-associated protein, 18kDa
Sin3A-associated protein, 18kDa
Sin3A-associated protein, 18kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:21140514-21149084
Strand Forward strand
Band q12.11
Transcripts
ENST00000382533 ENSP00000371973
ENST00000450573 ENSP00000391846
ENST00000485646
ENST00000492245 ENSP00000475435
ENST00000467636 ENSP00000475358
ENST00000471009
ENST00000607003 ENSP00000475925
ENST00000621421 ENSP00000481842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
Experimentally validated
Total 111 [view]
Protein-Protein 101 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 7 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0043065 positive regulation of apoptotic process
GO:0048025 negative regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0035145 exon-exon junction complex
GO:0061574 ASAP complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Hedgehog pathway
REACTOME
Epigenetic regulation of gene expression pathway
NoRC negatively regulates rRNA expression pathway
HDACs deacetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
Gene Expression pathway
Negative epigenetic regulation of rRNA expression pathway
KEGG
RNA transport pathway
mRNA surveillance pathway pathway
INOH
PID BIOCARTA
Mechanisms of transcriptional repression by dna methylation [Biocarta view]
PID NCI
Signaling events mediated by HDAC Class I
Regulation of nuclear SMAD2/3 signaling
Hedgehog signaling events mediated by Gli proteins
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631033 Hs.694971
RefSeq NM_005870
HUGO
OMIM
CCDS CCDS9295
HPRD 04256
IMGT
EMBL
GenPept
RNA Seq Atlas