Version 5.4
| Homo sapiens Gene: SAP18 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-14135.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | SAP18 | ||||||||||||||||||
| Gene Name | Sin3A-associated protein, 18kDa | ||||||||||||||||||
| Synonyms | 2HOR0202; SAP18P | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000150459 | ||||||||||||||||||
| Encoded Proteins |
Sin3A-associated protein, 18kDa
Sin3A-associated protein, 18kDa
Sin3A-associated protein, 18kDa
Sin3A-associated protein, 18kDa
Sin3A-associated protein, 18kDa
Sin3A-associated protein, 18kDa
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 13:21140514-21149084 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q12.11 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH |
Hedgehog pathway
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| REACTOME |
Epigenetic regulation of gene expression pathway
NoRC negatively regulates rRNA expression pathway
HDACs deacetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
Gene Expression pathway
Negative epigenetic regulation of rRNA expression pathway
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| KEGG |
RNA transport pathway
mRNA surveillance pathway pathway
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| INOH | |||||||||||||||||||
| PID NCI |
Signaling events mediated by HDAC Class I
Regulation of nuclear SMAD2/3 signaling
Hedgehog signaling events mediated by Gli proteins
Regulation of Telomerase
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.631033 Hs.694971 | ||||||||||||||||||
| RefSeq | NM_005870 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS9295 | ||||||||||||||||||
| HPRD | 04256 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||