Version 5.4
Mus musculus Protein: Ints5
Summary
InnateDB Protein IDBP-141530.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ints5
Protein Name integrator complex subunit 5
Synonyms 1110055N21Rik; mKIAA1698;
Species Mus musculus
Ensembl Protein ENSMUSP00000093968
InnateDB Gene IDBG-141528 (Ints5)
Protein Structure
UniProt Annotation
Function Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032039 integrator complex
Protein Structure and Domains
PDB ID MGI:1923578
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CHT3
PhosphoSite PhosphoSite-Q8CHT3
TrEMBL
UniProt Splice Variant
Entrez Gene 109077
UniGene Mm.290474
RefSeq NP_789813
MGI ID
MGI Symbol Ints5
OMIM
CCDS CCDS29556
HPRD
IMGT
EMBL AK155499 AK166149 AK168795 AK170584 BC039214
GenPept AAH39214 BAE33294 BAE38598 BAE40628 BAE41894

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca