InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Agtr1a

Summary

InnateDB Protein

IDBP-141629.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agtr1a

Protein Name

angiotensin II receptor, type 1a

Synonyms

1810074K20Rik; AG2S; Agtr-1a; Agtr1; AI551199; Angtr-1a; AT1; AT1a; AT2R1; AT2R1A;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070958

InnateDB Gene

IDBG-141627 (Agtr1a)

Protein Structure

UniProt Annotation

Function

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001596	angiotensin type I receptor activity
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0004945	angiotensin type II receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0019901	protein kinase binding
GO:0031748	D1 dopamine receptor binding
GO:0043621	protein self-association

Biological Process

GO:0001568	blood vessel development
GO:0001822	kidney development
GO:0001921	positive regulation of receptor recycling
GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0002001	renin secretion into blood stream
GO:0002018	renin-angiotensin regulation of aldosterone production
GO:0002019	regulation of renal output by angiotensin
GO:0002035	brain renin-angiotensin system
GO:0006885	regulation of pH
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007507	heart development
GO:0007568	aging
GO:0008284	positive regulation of cell proliferation
GO:0019229	regulation of vasoconstriction
GO:0032930	positive regulation of superoxide anion generation
GO:0034391	regulation of smooth muscle cell apoptotic process
GO:0034392	negative regulation of smooth muscle cell apoptotic process
GO:0042310	vasoconstriction
GO:0042416	dopamine biosynthetic process
GO:0042756	drinking behavior
GO:0042976	activation of Janus kinase activity
GO:0043627	response to estrogen
GO:0045777	positive regulation of blood pressure
GO:0050715	positive regulation of cytokine secretion
GO:0071549	cellular response to dexamethasone stimulus
GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030425	dendrite
GO:0031410	cytoplasmic vesicle
GO:0031968	organelle outer membrane
GO:0031983	vesicle lumen
GO:0055037	recycling endosome

Protein Structure and Domains

PDB ID

MGI:87964

InterPro

IPR000190 Angiotensin II receptor type 1
IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR000496 Bradykinin receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00635
PR00241
PR00237
PR00657
PR00425

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P29754