InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EFNA2

Summary

InnateDB Protein

IDBP-14208.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EFNA2

Protein Name

ephrin-A2

Synonyms

ELF-1; EPLG6; HEK7-L; LERK-6; LERK6;

Species

Homo sapiens

Ensembl Protein

ENSP00000215368

InnateDB Gene

IDBG-14206 (EFNA2)

Protein Structure

UniProt Annotation

Function

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0007267	cell-cell signaling
GO:0007411	axon guidance
GO:0021772	olfactory bulb development
GO:0030316	osteoclast differentiation
GO:0046849	bone remodeling
GO:0048013	ephrin receptor signaling pathway