Version 5.4
Mus musculus Protein: Serpinb1a
Summary
InnateDB Protein IDBP-142548.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serpinb1a
Protein Name serine (or cysteine) peptidase inhibitor, clade B, member 1a
Synonyms 1190005M04Rik; AI325983; EI; EIA; ELANH2; LEI; M/NEI; MNEI; PI2;
Species Mus musculus
Ensembl Protein ENSMUSP00000075690
InnateDB Gene IDBG-142542 (Serpinb1a)
Protein Structure
UniProt Annotation
Function Regulates the activity of the neutrophil proteases and thus, forms complexes with chymotrypsin, elastase, cathepsin G and proteinase-3. {ECO:0000269PubMed:12189154}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous with higher expression in pancreas, spleen and bone marrow. {ECO:0000269PubMed:11863365, ECO:0000269PubMed:12189154}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
GO:0042176 regulation of protein catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1913472
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D154
PhosphoSite PhosphoSite-Q9D154
TrEMBL
UniProt Splice Variant
Entrez Gene 66222
UniGene Mm.20144
RefSeq NP_079705
MGI ID
MGI Symbol Serpinb1a
OMIM
CCDS CCDS26428
HPRD
IMGT
EMBL AF426024 AF521697 AK003930 AK004500 AK008914 AK160167 AK160456 AL645808 BC011140 BC104333
GenPept AAH11140 AAI04334 AAL57486 AAM95933 BAB23079 BAB23335 BAB25964 BAE35668 BAE35797 CAI25648

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca