InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dcp1a

Summary

InnateDB Protein

IDBP-142611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dcp1a

Protein Name

DCP1 decapping enzyme homolog A (S. cerevisiae)

Synonyms

1110066A22Rik; 4930568L04Rik; AU019772; D14Ertd817e; Mitc1; SMIF;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022535

InnateDB Gene

IDBG-142609 (Dcp1a)

Protein Structure

UniProt Annotation

Function

Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000269PubMed:19861488}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (By similarity). Colocalizes with NANOS3 in the processing bodies. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008134	transcription factor binding
GO:0016787	hydrolase activity

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated