InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxo32

Summary

InnateDB Protein

IDBP-142943.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo32

Protein Name

F-box protein 32

Synonyms

4833442G10Rik; AI430017; ATROGIN1; Gm20361; MAFbx;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022986

InnateDB Gene

IDBG-142941 (Fbxo32)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between Cytoplasm and the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Specifically expressed in cardiac and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 159 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	159 [view]
Protein-Protein	158 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0014894	response to denervation involved in regulation of muscle adaptation
GO:0016567	protein ubiquitination
GO:0071549	cellular response to dexamethasone stimulus