Mus musculus Gene: Fbxo32
Summary
InnateDB Gene IDBG-142941.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxo32
Gene Name F-box protein 32
Synonyms 4833442G10Rik; AI430017; ATROGIN1; Gm20361; MAFbx;
Species Mus musculus
Ensembl Gene ENSMUSG00000022358
Encoded Proteins
F-box protein 32
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156804:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:58175879-58214892
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000022986 ENSMUSP00000022986
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 159 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 159 [view]
Protein-Protein 158 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0016567 protein ubiquitination
GO:0071549 cellular response to dexamethasone stimulus
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0030018 Z disc
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
FoxO family signaling
Cross-References
SwissProt Q9CPU7
TrEMBL
UniProt Splice Variant
Entrez Gene 67731
UniGene Mm.25683 Mm.410042
RefSeq NM_026346
OMIM
CCDS CCDS27491
HPRD
IMGT
MGI ID MGI:1914981
MGI Symbol Fbxo32
EMBL AF441120 AK014612 AK014793 BC027211
GenPept AAH27211 AAL49563 BAB29463 BAB29555
RNA Seq Atlas 67731