InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbxo32

Summary

InnateDB Gene

IDBG-142941.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo32

Gene Name

F-box protein 32

Synonyms

4833442G10Rik; AI430017; ATROGIN1; Gm20361; MAFbx;

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022358

Encoded Proteins

IDBP-142943

F-box protein 32

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156804:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:58175879-58214892

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022986

ENSMUSP00000022986

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 159 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	159 [view]
Protein-Protein	158 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0014894	response to denervation involved in regulation of muscle adaptation
GO:0016567	protein ubiquitination
GO:0071549	cellular response to dexamethasone stimulus

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0030018	Z disc

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSG00000156804

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000016194

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID BIOCARTA

PID NCI

foxopathway

FoxO family signaling

Cross-References

SwissProt

Q9CPU7

TrEMBL

UniProt Splice Variant

Entrez Gene

67731

UniGene

Mm.25683 Mm.410042

RefSeq

NM_026346

OMIM

CCDS

CCDS27491

HPRD

IMGT

MGI ID

MGI:1914981

MGI Symbol

Fbxo32

EMBL

AF441120 AK014612 AK014793 BC027211

GenPept

AAH27211 AAL49563 BAB29463 BAB29555

RNA Seq Atlas

67731