InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Elavl3

Summary

InnateDB Protein

IDBP-143029.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elavl3

Protein Name

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

Synonyms

2600009P04Rik; Huc; mHuC; PLE21;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003501

InnateDB Gene

IDBG-143027 (Elavl3)

Protein Structure

UniProt Annotation

Function

Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. {ECO:0000269PubMed:10734193, ECO:0000269PubMed:9016658}.

Subcellular Localization

Disease Associations

Tissue Specificity

Brain specific. {ECO:0000269PubMed:9016658}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0017091	AU-rich element binding

Biological Process

GO:0007399	nervous system development
GO:0030154	cell differentiation

Cellular Component

Protein Structure and Domains

PDB ID

MGI:109157

InterPro

IPR000504 RNA recognition motif domain
IPR002343 Paraneoplastic encephalomyelitis antigen
IPR003954 RNA recognition motif domain, eukaryote
IPR006548 Splicing factor ELAV/HuD

PFAM

PF00076

PRINTS

PR00961

PIRSF

SMART

SM00360
SM00361

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt