InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUBP1

Summary

InnateDB Protein

IDBP-14315.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUBP1

Protein Name

nucleotide binding protein 1

Synonyms

NBP; NBP1; NBP35;

Species

Homo sapiens

Ensembl Protein

ENSP00000283027

InnateDB Gene

IDBG-14313 (NUBP1)

Protein Structure

UniProt Annotation

Function

Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. {ECO:0000250, ECO:0000269PubMed:18573874}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03038, ECO:0000269PubMed:18573874}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0010826	negative regulation of centrosome duplication
GO:0016049	cell growth
GO:0016226	iron-sulfur cluster assembly
GO:0044281	small molecule metabolic process
GO:0051642	centrosome localization
GO:0072697	protein localization to cell cortex

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain
IPR003593 AAA+ ATPase domain
IPR015223 ATPase MipZ/NubP2/Cfd1
IPR019591 Mrp/NBP35 ATP-binding protein
IPR025723 Anion-transporting ATPase-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01656
PF09140
PF10609
PF02374

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P53384