Version 5.4
Mus musculus Protein: Fkbp3
Summary
InnateDB Protein IDBP-143172.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fkbp3
Protein Name FK506 binding protein 3
Synonyms 25kDa; FKBP-3; FKBP25;
Species Mus musculus
Ensembl Protein ENSMUSP00000021332
InnateDB Gene IDBG-143170 (Fkbp3)
Protein Structure
UniProt Annotation
Function FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0018208 peptidyl-proline modification
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1353460
InterPro IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
IPR013750 GHMP kinase, C-terminal domain
PFAM PF00254
PF08544
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62446
PhosphoSite PhosphoSite-Q62446
TrEMBL Q3UBU9
UniProt Splice Variant
Entrez Gene 30795
UniGene
RefSeq NP_038930
MGI ID 3KZ7
MGI Symbol Fkbp3
OMIM
CCDS CCDS25940
HPRD
IMGT
EMBL AF110812 AF135595 AK145648 AK150802 AK168641 BC002122 U62545
GenPept AAB05769 AAD20598 AAD25097 AAH02122 BAE26564 BAE29865 BAE40500

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca