Version 5.4
Mus musculus Gene: Fkbp3
Summary
InnateDB Gene IDBG-143170.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fkbp3
Gene Name FK506 binding protein 3
Synonyms 25kDa; FKBP-3; FKBP25
Species Mus musculus
Ensembl Gene ENSMUSG00000020949
Encoded Proteins
IDBP-143172
FK506 binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100442:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:65062436-65073944
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000021332 ENSMUSP00000021332
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0018208 peptidyl-proline modification
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100442
View Gene Order
ENSBTAG00000002610
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
Cross-References
SwissProt Q62446
TrEMBL Q3UBU9
UniProt Splice Variant
Entrez Gene 30795
UniGene
RefSeq NM_013902
OMIM
CCDS CCDS25940
HPRD
IMGT
MGI ID MGI:1353460
MGI Symbol Fkbp3
EMBL AF110812 AF135595 AK145648 AK150802 AK168641 BC002122 U62545
GenPept AAB05769 AAD20598 AAD25097 AAH02122 BAE26564 BAE29865 BAE40500
RNA Seq Atlas 30795

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca